Yo lo he solucionado asi para w7x64:

1. Instalar netframework 4.5.2

https://download.microsoft.com/download/E/2/1/E21644B5-2DF2-47C2-91BD-63C560427900/NDP452-KB2901907-x86-x64-AllOS-ENU.exe

2. Instalar KB2999226

https://download.microsoft.com/download/1/1/5/11565A9A-EA09-4F0A-A57E-520D5D138140/Windows6.1-KB2999226-x64.msu

3. Desactivar UAC

4. Usar Driver Signature Enforcement Overrider (dseo13b) para activar arranque seguro sin firmas

https://free.nchc.org.tw/osdn//users/7/7391/dseo13b.exe

5. Instalar ultima version del driver Wacom

https://www.wacom.com/es-es/support/product-support/drivers?driver-search=ctl-4100#

7. Probar